This study is of particular note because it was published in the British Medical Journal, not in an ophthalmology journal. 8Īn example of a meta-analysis in glaucoma therapy is the study by Maier et al., 13 which addressed whether lowering of IOP delays the progression of visual field defects in patients with open-angle glaucoma. 18 Meta-analyses can be useful for reducing the biases and improving the precision that is associated with RCTs. Forest plots are a convenient way of summarizing the statistical analyses performed on the studies used for the meta-analyses ( Fig. The averages of the study results are often weighted, placing more emphasis on larger studies. 17 Meta-analyses are particularly useful when there are small clinical trials that are inconclusive, perhaps because of size, and when different RCTs come to different conclusions. By combining the outcomes of multiple studies, the overall sample size and statistical power are increased. In a meta-analysis, statistical techniques are used to measure and compare the outcomes of multiple studies. When multiple RCTs have been conducted on a given topic, a meta-analysis can be employed. Myron Yanoff MD, in Ophthalmology, 2019 Meta-Analyses and Systematic Reviews
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